rs952715
Variant in the GZMB gene (Granzyme B)
rs952715 is a single nucleotide polymorphism (SNP) in the GZMB gene, involved in cytotoxic killing. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs952715 variant?
rs952715 is a SNP (single nucleotide polymorphism) in the GZMB (Granzyme B) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. Granzyme B is the principal apoptosis-inducing serine protease delivered by perforin pores into target cells. It cleaves caspases, BID, and other substrates to execute programmed cell death and is critical for CTL and NK cell cytotoxicity.
Biological role and pathway
This variant sits within the GZMB gene, which is involved in the cytotoxic killing pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs952715 and Long COVID / ME-CFS research
Elevated granzyme B from activated NK and T cells has been documented in COVID-19 plasma, contributing to vascular damage. GzB can degrade ECM components; abnormal levels may contribute to tissue damage or impaired cytotoxic control of persistent SARS-CoV-2 reservoirs in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: GZMB
rs952715 is one of 3 known variants in the GZMB gene. To understand the full biological context of this variant, explore the parent gene page.
View GZMB gene page →Conditions studied in relation to rs952715
Research into GZMB variants including rs952715 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include GZMB and the rs952715 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the GZMB gene
The following variants in GZMB are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs952715 variant in the GZMB gene?
rs952715 is a single nucleotide polymorphism (SNP) located in the GZMB (Granzyme B) gene, which is involved in cytotoxic killing. Granzyme B is the principal apoptosis-inducing serine protease delivered by perforin pores into target cells. It cleaves caspases, BID, and other substrates to execute programmed cell death and is critical for CTL and NK cell cytotoxicity.
How may the rs952715 variant relate to Long COVID or ME/CFS?
Elevated granzyme B from activated NK and T cells has been documented in COVID-19 plasma, contributing to vascular damage. GzB can degrade ECM components; abnormal levels may contribute to tissue damage or impaired cytotoxic control of persistent SARS-CoV-2 reservoirs in Long COVID.
Can a consumer DNA test detect the rs952715 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs952715 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for GZMB and its variants. This is not an exhaustive literature review.
- [1]PMID: 33122441
- [2]Nature Immunology
- [3]Cell Reports