rs1049255

What is the rs1049255 variant?

rs1049255 is a SNP (single nucleotide polymorphism) in the HADHA (Hydroxyacyl-CoA Dehydrogenase Trifunctional Protein Alpha Subunit) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. HADHA encodes the alpha subunit of mitochondrial trifunctional protein (MTP), performing three steps of long-chain fatty acid oxidation.

Biological role and pathway

This variant sits within the HADHA gene, which is involved in the long-chain fatty acid beta-oxidation pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HADHA

rs1049255 is one of 1 known variant in the HADHA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1049255

Research into HADHA variants including rs1049255 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HADHA and the rs1049255 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HADHA gene

The following variants in HADHA are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions