rs34451549

What is the rs34451549 variant?

rs34451549 is a SNP (single nucleotide polymorphism) in the HBA1 (Hemoglobin Subunit Alpha 1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. HBA1 encodes alpha-globin, one of two alpha-globin chains of adult hemoglobin, essential for oxygen transport.

Biological role and pathway

This variant sits within the HBA1 gene, which is involved in the oxygen transport / hemoglobin pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HBA1

rs34451549 is one of 1 known variant in the HBA1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs34451549

Research into HBA1 variants including rs34451549 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HBA1 and the rs34451549 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions