rs2290095
Variant in the HERC5 gene (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5)
rs2290095 is a single nucleotide polymorphism (SNP) in the HERC5 gene, involved in ISGylation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2290095 variant?
rs2290095 is a SNP (single nucleotide polymorphism) in the HERC5 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. HERC5 is an interferon-stimulated E3 ISG15 ligase that conjugates ISG15 to newly synthesized proteins in a co-translational manner. ISGylation broadly restricts viral replication by modifying host translation and viral protein function.
Biological role and pathway
This variant sits within the HERC5 gene, which is involved in the ISGylation pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2290095 and Long COVID / ME-CFS research
ISGylation is a major component of the antiviral interferon response. HERC5 variants may affect the breadth of ISG15-mediated protein modification during SARS-CoV-2 infection, influencing viral control and interferon pathway activation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HERC5
rs2290095 is one of 2 known variants in the HERC5 gene. To understand the full biological context of this variant, explore the parent gene page.
View HERC5 gene page →Conditions studied in relation to rs2290095
Research into HERC5 variants including rs2290095 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HERC5 and the rs2290095 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HERC5 gene
The following variants in HERC5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2290095 variant in the HERC5 gene?
rs2290095 is a single nucleotide polymorphism (SNP) located in the HERC5 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5) gene, which is involved in ISGylation. HERC5 is an interferon-stimulated E3 ISG15 ligase that conjugates ISG15 to newly synthesized proteins in a co-translational manner. ISGylation broadly restricts viral replication by modifying host translation and viral protein function.
How may the rs2290095 variant relate to Long COVID or ME/CFS?
ISGylation is a major component of the antiviral interferon response. HERC5 variants may affect the breadth of ISG15-mediated protein modification during SARS-CoV-2 infection, influencing viral control and interferon pathway activation in Long COVID.
Can a consumer DNA test detect the rs2290095 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2290095 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for HERC5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 26456807
- [2]Nature Immunology
- [3]Cell Host & Microbe