rs4680863

What is the rs4680863 variant?

rs4680863 is a SNP (single nucleotide polymorphism) in the HES1 (Hes Family BHLH Transcription Factor 1) gene. It belongs to the Signaling category and is part of the Neurological & Cognitive Function biological cluster. HES1 encodes a Notch target basic helix-loop-helix transcriptional repressor involved in neural and immune cell differentiation.

Biological role and pathway

This variant sits within the HES1 gene, which is involved in the Notch target / transcriptional repressor pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HES1

rs4680863 is one of 1 known variant in the HES1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4680863

Research into HES1 variants including rs4680863 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HES1 and the rs4680863 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions