rs1800562
Variant in the HFE gene (Homeostatic Iron Regulator)
rs1800562 is a single nucleotide polymorphism (SNP) in the HFE gene, involved in iron homeostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1800562 variant?
rs1800562 is a SNP (single nucleotide polymorphism) in the HFE (Homeostatic Iron Regulator) gene. It belongs to the Vitamin Metabolism category and is part of the Vitamin & Nutrient Metabolism biological cluster. HFE encodes the hereditary hemochromatosis protein that regulates iron absorption and the hepcidin signaling pathway.
Biological role and pathway
This variant sits within the HFE gene, which is involved in the iron homeostasis pathway. Genes within the Vitamin & Nutrient Metabolism cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1800562 and Long COVID / ME-CFS research
HFE variants affecting iron homeostasis may contribute to iron-driven inflammatory processes and fatigue in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HFE
rs1800562 is one of 2 known variants in the HFE gene. To understand the full biological context of this variant, explore the parent gene page.
View HFE gene page →Conditions studied in relation to rs1800562
Research into HFE variants including rs1800562 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HFE and the rs1800562 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HFE gene
The following variants in HFE are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1800562 variant in the HFE gene?
rs1800562 is a single nucleotide polymorphism (SNP) located in the HFE (Homeostatic Iron Regulator) gene, which is involved in iron homeostasis. HFE encodes the hereditary hemochromatosis protein that regulates iron absorption and the hepcidin signaling pathway.
How may the rs1800562 variant relate to Long COVID or ME/CFS?
HFE variants affecting iron homeostasis may contribute to iron-driven inflammatory processes and fatigue in Long COVID.
Can a consumer DNA test detect the rs1800562 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1800562 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for HFE and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation