rs11553049

What is the rs11553049 variant?

rs11553049 is a SNP (single nucleotide polymorphism) in the HK1 (Hexokinase 1) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. HK1 encodes hexokinase 1, which phosphorylates glucose to glucose-6-phosphate as the first committed step of glycolysis.

Biological role and pathway

This variant sits within the HK1 gene, which is involved in the glycolysis initiation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HK1

rs11553049 is one of 1 known variant in the HK1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs11553049

Research into HK1 variants including rs11553049 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HK1 and the rs11553049 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions