rs2571381
Variant in the HLA-A gene (Major Histocompatibility Complex Class I A)
rs2571381 is a single nucleotide polymorphism (SNP) in the HLA-A gene, involved in MHC class I antigen presentation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2571381 variant?
rs2571381 is a SNP (single nucleotide polymorphism) in the HLA-A (Major Histocompatibility Complex Class I A) gene. It belongs to the Immune Presentation category and is part of the HLA & Immune Presentation biological cluster. HLA-A encodes an MHC class I molecule that presents intracellular peptides to cytotoxic CD8+ T lymphocytes.
Biological role and pathway
This variant sits within the HLA-A gene, which is involved in the MHC class I antigen presentation pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2571381 and Long COVID / ME-CFS research
HLA-A alleles determine the repertoire of viral peptides presented to cytotoxic T cells and may influence Long COVID immune memory.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HLA-A
rs2571381 is one of 2 known variants in the HLA-A gene. To understand the full biological context of this variant, explore the parent gene page.
View HLA-A gene page →Conditions studied in relation to rs2571381
Research into HLA-A variants including rs2571381 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HLA-A and the rs2571381 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HLA-A gene
The following variants in HLA-A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2571381 variant in the HLA-A gene?
rs2571381 is a single nucleotide polymorphism (SNP) located in the HLA-A (Major Histocompatibility Complex Class I A) gene, which is involved in MHC class I antigen presentation. HLA-A encodes an MHC class I molecule that presents intracellular peptides to cytotoxic CD8+ T lymphocytes.
How may the rs2571381 variant relate to Long COVID or ME/CFS?
HLA-A alleles determine the repertoire of viral peptides presented to cytotoxic T cells and may influence Long COVID immune memory.
Can a consumer DNA test detect the rs2571381 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2571381 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HLA-A and its variants. This is not an exhaustive literature review.
- [1]PMID: 33888513
- [2]Nature Genetics
- [3]Journal of Clinical Investigation