rs9264942

What is the rs9264942 variant?

rs9264942 is a SNP (single nucleotide polymorphism) in the HLA-B (Major Histocompatibility Complex Class I B) gene. It belongs to the Immune Presentation category and is part of the HLA & Immune Presentation biological cluster. HLA-B encodes an MHC class I molecule that presents intracellular peptides to cytotoxic CD8+ T cells.

Biological role and pathway

This variant sits within the HLA-B gene, which is involved in the MHC class I antigen presentation pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HLA-B

rs9264942 is one of 1 known variant in the HLA-B gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs9264942

Research into HLA-B variants including rs9264942 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HLA-B and the rs9264942 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions