rs660895
Variant in the HLA-DRB1 gene (Major Histocompatibility Complex Class II DR Beta 1)
rs660895 is a single nucleotide polymorphism (SNP) in the HLA-DRB1 gene, involved in MHC class II antigen presentation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs660895 variant?
rs660895 is a SNP (single nucleotide polymorphism) in the HLA-DRB1 (Major Histocompatibility Complex Class II DR Beta 1) gene. It belongs to the Immune Presentation category and is part of the HLA & Immune Presentation biological cluster. HLA-DRB1 is one of the most polymorphic genes in the human genome, encoding a key antigen-presenting molecule.
Biological role and pathway
This variant sits within the HLA-DRB1 gene, which is involved in the MHC class II antigen presentation pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs660895 and Long COVID / ME-CFS research
Specific HLA-DRB1 alleles are associated with autoimmune conditions and may influence Long COVID risk and symptom severity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HLA-DRB1
rs660895 is one of 1 known variant in the HLA-DRB1 gene. To understand the full biological context of this variant, explore the parent gene page.
View HLA-DRB1 gene page →Conditions studied in relation to rs660895
Research into HLA-DRB1 variants including rs660895 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HLA-DRB1 and the rs660895 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs660895 variant in the HLA-DRB1 gene?
rs660895 is a single nucleotide polymorphism (SNP) located in the HLA-DRB1 (Major Histocompatibility Complex Class II DR Beta 1) gene, which is involved in MHC class II antigen presentation. HLA-DRB1 is one of the most polymorphic genes in the human genome, encoding a key antigen-presenting molecule.
How may the rs660895 variant relate to Long COVID or ME/CFS?
Specific HLA-DRB1 alleles are associated with autoimmune conditions and may influence Long COVID risk and symptom severity.
Can a consumer DNA test detect the rs660895 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs660895 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HLA-DRB1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33888513
- [2]Nature Genetics
- [3]Journal of Clinical Investigation