rs17244841
Variant in the HMGCR gene (3-Hydroxy-3-Methylglutaryl-CoA Reductase)
rs17244841 is a single nucleotide polymorphism (SNP) in the HMGCR gene, involved in cholesterol biosynthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs17244841 variant?
rs17244841 is a SNP (single nucleotide polymorphism) in the HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) gene. It belongs to the Lipid Metabolism category and is part of the Lipid Metabolism biological cluster. HMGCR encodes HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway and target of statin drugs.
Biological role and pathway
This variant sits within the HMGCR gene, which is involved in the cholesterol biosynthesis pathway. Genes within the Lipid Metabolism cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs17244841 and Long COVID / ME-CFS research
HMGCR variants affecting cholesterol synthesis may influence immune cell membrane composition and statin response in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HMGCR
rs17244841 is one of 3 known variants in the HMGCR gene. To understand the full biological context of this variant, explore the parent gene page.
View HMGCR gene page →Conditions studied in relation to rs17244841
Research into HMGCR variants including rs17244841 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HMGCR and the rs17244841 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HMGCR gene
The following variants in HMGCR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs17244841 variant in the HMGCR gene?
rs17244841 is a single nucleotide polymorphism (SNP) located in the HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) gene, which is involved in cholesterol biosynthesis. HMGCR encodes HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway and target of statin drugs.
How may the rs17244841 variant relate to Long COVID or ME/CFS?
HMGCR variants affecting cholesterol synthesis may influence immune cell membrane composition and statin response in Long COVID.
Can a consumer DNA test detect the rs17244841 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs17244841 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HMGCR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Journal of Clinical Investigation