rs1169288
Variant in the HNF1A gene (Hepatocyte Nuclear Factor 1-Alpha)
rs1169288 is a single nucleotide polymorphism (SNP) in the HNF1A gene, involved in MODY3 / liver and pancreas gene regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1169288 variant?
rs1169288 is a SNP (single nucleotide polymorphism) in the HNF1A (Hepatocyte Nuclear Factor 1-Alpha) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. HNF1A encodes a transcription factor critical for liver, kidney, and pancreatic beta cell function; mutations cause MODY3.
Biological role and pathway
This variant sits within the HNF1A gene, which is involved in the MODY3 / liver and pancreas gene regulation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1169288 and Long COVID / ME-CFS research
HNF1A variants affect glucose metabolism and hepatic function; given post-COVID liver involvement and new-onset diabetes, HNF1A variants may influence metabolic complications in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HNF1A
rs1169288 is one of 2 known variants in the HNF1A gene. To understand the full biological context of this variant, explore the parent gene page.
View HNF1A gene page →Conditions studied in relation to rs1169288
Research into HNF1A variants including rs1169288 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HNF1A and the rs1169288 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the HNF1A gene
The following variants in HNF1A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1169288 variant in the HNF1A gene?
rs1169288 is a single nucleotide polymorphism (SNP) located in the HNF1A (Hepatocyte Nuclear Factor 1-Alpha) gene, which is involved in MODY3 / liver and pancreas gene regulation. HNF1A encodes a transcription factor critical for liver, kidney, and pancreatic beta cell function; mutations cause MODY3.
How may the rs1169288 variant relate to Long COVID or ME/CFS?
HNF1A variants affect glucose metabolism and hepatic function; given post-COVID liver involvement and new-onset diabetes, HNF1A variants may influence metabolic complications in Long COVID.
Can a consumer DNA test detect the rs1169288 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1169288 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HNF1A and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM