rs1884613

What is the rs1884613 variant?

rs1884613 is a SNP (single nucleotide polymorphism) in the HNF4A (Hepatocyte Nuclear Factor 4 Alpha) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. HNF4A is a nuclear receptor critical for hepatic lipid and glucose metabolism and pancreatic beta cell function; mutations cause MODY1.

Biological role and pathway

This variant sits within the HNF4A gene, which is involved in the hepatic gene regulation / MODY1 pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HNF4A

rs1884613 is one of 2 known variants in the HNF4A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1884613

Research into HNF4A variants including rs1884613 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HNF4A and the rs1884613 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the HNF4A gene

The following variants in HNF4A are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions