rs4704

What is the rs4704 variant?

rs4704 is a SNP (single nucleotide polymorphism) in the HOMER1 (Homer Scaffold Protein 1) gene. It belongs to the Neurological category and is part of the Neurological & Cognitive Function biological cluster. HOMER1 encodes a postsynaptic scaffold protein that links mGluR5 to the postsynaptic density and regulates synaptic signaling.

Biological role and pathway

This variant sits within the HOMER1 gene, which is involved in the postsynaptic density / glutamate receptor coupling pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HOMER1

rs4704 is one of 1 known variant in the HOMER1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4704

Research into HOMER1 variants including rs4704 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HOMER1 and the rs4704 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions