rs1832580
Variant in the HSD11B2 gene (Hydroxysteroid 11-Beta Dehydrogenase 2)
rs1832580 is a single nucleotide polymorphism (SNP) in the HSD11B2 gene, involved in cortisol inactivation / kidney mineralocorticoid protection. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1832580 variant?
rs1832580 is a SNP (single nucleotide polymorphism) in the HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2) gene. It belongs to the Metabolic category and is part of the Autonomic Nervous System biological cluster. HSD11B2 encodes 11β-hydroxysteroid dehydrogenase 2, which inactivates cortisol to cortisone in the kidney, preventing cortisol from activating mineralocorticoid receptors.
Biological role and pathway
This variant sits within the HSD11B2 gene, which is involved in the cortisol inactivation / kidney mineralocorticoid protection pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1832580 and Long COVID / ME-CFS research
HSD11B2 protects mineralocorticoid receptors from cortisol; variants causing apparent mineralocorticoid excess may contribute to dysautonomia and fluid balance issues in Long COVID POTS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: HSD11B2
rs1832580 is one of 1 known variant in the HSD11B2 gene. To understand the full biological context of this variant, explore the parent gene page.
View HSD11B2 gene page →Conditions studied in relation to rs1832580
Research into HSD11B2 variants including rs1832580 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HSD11B2 and the rs1832580 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1832580 variant in the HSD11B2 gene?
rs1832580 is a single nucleotide polymorphism (SNP) located in the HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2) gene, which is involved in cortisol inactivation / kidney mineralocorticoid protection. HSD11B2 encodes 11β-hydroxysteroid dehydrogenase 2, which inactivates cortisol to cortisone in the kidney, preventing cortisol from activating mineralocorticoid receptors.
How may the rs1832580 variant relate to Long COVID or ME/CFS?
HSD11B2 protects mineralocorticoid receptors from cortisol; variants causing apparent mineralocorticoid excess may contribute to dysautonomia and fluid balance issues in Long COVID POTS.
Can a consumer DNA test detect the rs1832580 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1832580 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for HSD11B2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Hypertension