rs1043618

What is the rs1043618 variant?

rs1043618 is a SNP (single nucleotide polymorphism) in the HSPA1A (Heat Shock Protein Family A Member 1A (HSP70)) gene. It belongs to the Stress Response category and is part of the Cellular Signaling biological cluster. HSPA1A encodes HSP70-1, the major inducible heat shock protein that prevents protein aggregation under cellular stress.

Biological role and pathway

This variant sits within the HSPA1A gene, which is involved in the protein quality and stress response pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HSPA1A

rs1043618 is one of 1 known variant in the HSPA1A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1043618

Research into HSPA1A variants including rs1043618 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HSPA1A and the rs1043618 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions