rs2273633

What is the rs2273633 variant?

rs2273633 is a SNP (single nucleotide polymorphism) in the HYAL2 (Hyaluronidase 2) gene. It belongs to the Connective Tissue category and is part of the Immune System & Inflammation biological cluster. HYAL2 encodes hyaluronidase 2, which cleaves hyaluronic acid and also serves as the cellular receptor for certain retroviruses.

Biological role and pathway

This variant sits within the HYAL2 gene, which is involved in the hyaluronan degradation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: HYAL2

rs2273633 is one of 1 known variant in the HYAL2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2273633

Research into HYAL2 variants including rs2273633 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include HYAL2 and the rs2273633 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions