rs1799969
Variant in the ICAM1 gene (Intercellular Adhesion Molecule 1)
rs1799969 is a single nucleotide polymorphism (SNP) in the ICAM1 gene, involved in leukocyte adhesion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799969 variant?
rs1799969 is a SNP (single nucleotide polymorphism) in the ICAM1 (Intercellular Adhesion Molecule 1) gene. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. ICAM-1 (CD54) is the endothelial adhesion molecule that stabilizes leukocyte attachment by binding LFA-1 (αLβ2) and Mac-1 (αMβ2). It is constitutively expressed and strongly upregulated by inflammatory cytokines.
Biological role and pathway
This variant sits within the ICAM1 gene, which is involved in the leukocyte adhesion pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799969 and Long COVID / ME-CFS research
Soluble ICAM-1 is elevated in Long COVID as a marker of endothelial inflammation. ICAM-1 is also the receptor for rhinoviruses and SARS-CoV (though not SARS-CoV-2). ICAM1 variants affecting endothelial activation threshold may modulate Long COVID vascular inflammation.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ICAM1
rs1799969 is one of 3 known variants in the ICAM1 gene. To understand the full biological context of this variant, explore the parent gene page.
View ICAM1 gene page →Conditions studied in relation to rs1799969
Research into ICAM1 variants including rs1799969 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ICAM1 and the rs1799969 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ICAM1 gene
The following variants in ICAM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799969 variant in the ICAM1 gene?
rs1799969 is a single nucleotide polymorphism (SNP) located in the ICAM1 (Intercellular Adhesion Molecule 1) gene, which is involved in leukocyte adhesion. ICAM-1 (CD54) is the endothelial adhesion molecule that stabilizes leukocyte attachment by binding LFA-1 (αLβ2) and Mac-1 (αMβ2). It is constitutively expressed and strongly upregulated by inflammatory cytokines.
How may the rs1799969 variant relate to Long COVID or ME/CFS?
Soluble ICAM-1 is elevated in Long COVID as a marker of endothelial inflammation. ICAM-1 is also the receptor for rhinoviruses and SARS-CoV (though not SARS-CoV-2). ICAM1 variants affecting endothelial activation threshold may modulate Long COVID vascular inflammation.
Can a consumer DNA test detect the rs1799969 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799969 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ICAM1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 31043580
- [2]Nature Reviews Immunology
- [3]Arteriosclerosis Thrombosis and Vascular Biology