rs1059293
Variant in the IFIT1 gene (Interferon Induced Protein With Tetratricopeptide Repeats 1)
rs1059293 is a single nucleotide polymorphism (SNP) in the IFIT1 gene, involved in interferon-stimulated gene response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1059293 variant?
rs1059293 is a SNP (single nucleotide polymorphism) in the IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. IFIT1 is a strongly interferon-induced antiviral protein that recognizes and sequesters viral RNA bearing 5'-triphosphate groups.
Biological role and pathway
This variant sits within the IFIT1 gene, which is involved in the interferon-stimulated gene response pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1059293 and Long COVID / ME-CFS research
IFIT1 is one of the most robustly induced antiviral genes; variants in regulatory regions may affect antiviral gene expression in response to SARS-CoV-2.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IFIT1
rs1059293 is one of 1 known variant in the IFIT1 gene. To understand the full biological context of this variant, explore the parent gene page.
View IFIT1 gene page →Conditions studied in relation to rs1059293
Research into IFIT1 variants including rs1059293 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IFIT1 and the rs1059293 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1059293 variant in the IFIT1 gene?
rs1059293 is a single nucleotide polymorphism (SNP) located in the IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) gene, which is involved in interferon-stimulated gene response. IFIT1 is a strongly interferon-induced antiviral protein that recognizes and sequesters viral RNA bearing 5'-triphosphate groups.
How may the rs1059293 variant relate to Long COVID or ME/CFS?
IFIT1 is one of the most robustly induced antiviral genes; variants in regulatory regions may affect antiviral gene expression in response to SARS-CoV-2.
Can a consumer DNA test detect the rs1059293 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1059293 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IFIT1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Genetics
- [3]Nature Immunology