rs6214
Variant in the IGF1 gene (Insulin-Like Growth Factor 1)
rs6214 is a single nucleotide polymorphism (SNP) in the IGF1 gene, involved in GH-IGF1 axis / anabolic signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6214 variant?
rs6214 is a SNP (single nucleotide polymorphism) in the IGF1 (Insulin-Like Growth Factor 1) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. IGF1 encodes insulin-like growth factor 1, the primary GH-induced anabolic mediator that promotes cell growth and survival via PI3K/AKT signaling.
Biological role and pathway
This variant sits within the IGF1 gene, which is involved in the GH-IGF1 axis / anabolic signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6214 and Long COVID / ME-CFS research
IGF-1 levels decline with illness and inflammation; low IGF-1 in Long COVID may impair muscle, cognitive, and cardiac recovery, with IGF1 variants affecting baseline levels.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IGF1
rs6214 is one of 2 known variants in the IGF1 gene. To understand the full biological context of this variant, explore the parent gene page.
View IGF1 gene page →Conditions studied in relation to rs6214
Research into IGF1 variants including rs6214 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IGF1 and the rs6214 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IGF1 gene
The following variants in IGF1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6214 variant in the IGF1 gene?
rs6214 is a single nucleotide polymorphism (SNP) located in the IGF1 (Insulin-Like Growth Factor 1) gene, which is involved in GH-IGF1 axis / anabolic signaling. IGF1 encodes insulin-like growth factor 1, the primary GH-induced anabolic mediator that promotes cell growth and survival via PI3K/AKT signaling.
How may the rs6214 variant relate to Long COVID or ME/CFS?
IGF-1 levels decline with illness and inflammation; low IGF-1 in Long COVID may impair muscle, cognitive, and cardiac recovery, with IGF1 variants affecting baseline levels.
Can a consumer DNA test detect the rs6214 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6214 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IGF1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]JCEM