rs2854744
Variant in the IGFBP3 gene (Insulin-Like Growth Factor Binding Protein 3)
rs2854744 is a single nucleotide polymorphism (SNP) in the IGFBP3 gene, involved in IGF bioavailability regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2854744 variant?
rs2854744 is a SNP (single nucleotide polymorphism) in the IGFBP3 (Insulin-Like Growth Factor Binding Protein 3) gene. It belongs to the Neuroendocrine category and is part of the Metabolic Regulation biological cluster. IGFBP3 encodes the major carrier of circulating IGF-1, extending its half-life and modulating its bioavailability.
Biological role and pathway
This variant sits within the IGFBP3 gene, which is involved in the IGF bioavailability regulation pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2854744 and Long COVID / ME-CFS research
IGFBP3 regulates IGF-1 bioavailability; variants may affect the effective IGF-1 levels available for tissue repair and anabolic functions in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IGFBP3
rs2854744 is one of 2 known variants in the IGFBP3 gene. To understand the full biological context of this variant, explore the parent gene page.
View IGFBP3 gene page →Conditions studied in relation to rs2854744
Research into IGFBP3 variants including rs2854744 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IGFBP3 and the rs2854744 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IGFBP3 gene
The following variants in IGFBP3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2854744 variant in the IGFBP3 gene?
rs2854744 is a single nucleotide polymorphism (SNP) located in the IGFBP3 (Insulin-Like Growth Factor Binding Protein 3) gene, which is involved in IGF bioavailability regulation. IGFBP3 encodes the major carrier of circulating IGF-1, extending its half-life and modulating its bioavailability.
How may the rs2854744 variant relate to Long COVID or ME/CFS?
IGFBP3 regulates IGF-1 bioavailability; variants may affect the effective IGF-1 levels available for tissue repair and anabolic functions in Long COVID.
Can a consumer DNA test detect the rs2854744 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2854744 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IGFBP3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]JCEM