rs35000281
Variant in the IGHM gene (Immunoglobulin Heavy Constant Mu)
rs35000281 is a single nucleotide polymorphism (SNP) in the IGHM gene, involved in B cell function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs35000281 variant?
rs35000281 is a SNP (single nucleotide polymorphism) in the IGHM (Immunoglobulin Heavy Constant Mu) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. IGHM encodes the heavy chain constant region of IgM antibodies, the first immunoglobulin class produced in humoral responses and a major component of the pre-BCR in B cell development.
Biological role and pathway
This variant sits within the IGHM gene, which is involved in the B cell function pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs35000281 and Long COVID / ME-CFS research
IgM levels and dynamics in COVID-19 inform early immune response kinetics. IGHM variants affecting IgM production or signaling may influence B cell development and the early antibody responses that shape subsequent Long COVID predisposition.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IGHM
rs35000281 is one of 2 known variants in the IGHM gene. To understand the full biological context of this variant, explore the parent gene page.
View IGHM gene page →Conditions studied in relation to rs35000281
Research into IGHM variants including rs35000281 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IGHM and the rs35000281 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IGHM gene
The following variants in IGHM are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs35000281 variant in the IGHM gene?
rs35000281 is a single nucleotide polymorphism (SNP) located in the IGHM (Immunoglobulin Heavy Constant Mu) gene, which is involved in B cell function. IGHM encodes the heavy chain constant region of IgM antibodies, the first immunoglobulin class produced in humoral responses and a major component of the pre-BCR in B cell development.
How may the rs35000281 variant relate to Long COVID or ME/CFS?
IgM levels and dynamics in COVID-19 inform early immune response kinetics. IGHM variants affecting IgM production or signaling may influence B cell development and the early antibody responses that shape subsequent Long COVID predisposition.
Can a consumer DNA test detect the rs35000281 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs35000281 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IGHM and its variants. This is not an exhaustive literature review.
- [1]PMID: 28892065
- [2]Journal of Immunology
- [3]Nature Immunology