rs2241096
Variant in the IKBKE gene (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon)
rs2241096 is a single nucleotide polymorphism (SNP) in the IKBKE gene, involved in interferon signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2241096 variant?
rs2241096 is a SNP (single nucleotide polymorphism) in the IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. IKBKE (IKKε) is a non-canonical IKK family kinase that phosphorylates IRF3 and IRF7 alongside TBK1. It also activates NF-κB and STAT1 and is involved in innate immune regulation and oncogenesis.
Biological role and pathway
This variant sits within the IKBKE gene, which is involved in the interferon signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2241096 and Long COVID / ME-CFS research
IKBKE participates in both antiviral interferon production and the NF-κB-dependent cytokine storm. Variants affecting IKBKE activity may influence the balance between effective antiviral responses and excessive inflammation relevant to COVID-19 severity and Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IKBKE
rs2241096 is one of 2 known variants in the IKBKE gene. To understand the full biological context of this variant, explore the parent gene page.
View IKBKE gene page →Conditions studied in relation to rs2241096
Research into IKBKE variants including rs2241096 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IKBKE and the rs2241096 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IKBKE gene
The following variants in IKBKE are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2241096 variant in the IKBKE gene?
rs2241096 is a single nucleotide polymorphism (SNP) located in the IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) gene, which is involved in interferon signaling. IKBKE (IKKε) is a non-canonical IKK family kinase that phosphorylates IRF3 and IRF7 alongside TBK1. It also activates NF-κB and STAT1 and is involved in innate immune regulation and oncogenesis.
How may the rs2241096 variant relate to Long COVID or ME/CFS?
IKBKE participates in both antiviral interferon production and the NF-κB-dependent cytokine storm. Variants affecting IKBKE activity may influence the balance between effective antiviral responses and excessive inflammation relevant to COVID-19 severity and Long COVID.
Can a consumer DNA test detect the rs2241096 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2241096 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IKBKE and its variants. This is not an exhaustive literature review.
- [1]PMID: 29728542
- [2]Nature Immunology
- [3]Cell