rs11978267
Variant in the IKZF1 gene (IKAROS Family Zinc Finger 1)
rs11978267 is a single nucleotide polymorphism (SNP) in the IKZF1 gene, involved in hematopoietic transcription / lymphocyte development. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11978267 variant?
rs11978267 is a SNP (single nucleotide polymorphism) in the IKZF1 (IKAROS Family Zinc Finger 1) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IKZF1 encodes Ikaros, a master transcription factor for lymphoid cell development controlling T cell, B cell, and NK cell differentiation.
Biological role and pathway
This variant sits within the IKZF1 gene, which is involved in the hematopoietic transcription / lymphocyte development pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11978267 and Long COVID / ME-CFS research
Ikaros regulates lymphocyte development and immunological diversity; IKZF1 variants are associated with immune deficiencies and ALL; variants may affect immune competence in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IKZF1
rs11978267 is one of 2 known variants in the IKZF1 gene. To understand the full biological context of this variant, explore the parent gene page.
View IKZF1 gene page →Conditions studied in relation to rs11978267
Research into IKZF1 variants including rs11978267 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IKZF1 and the rs11978267 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IKZF1 gene
The following variants in IKZF1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11978267 variant in the IKZF1 gene?
rs11978267 is a single nucleotide polymorphism (SNP) located in the IKZF1 (IKAROS Family Zinc Finger 1) gene, which is involved in hematopoietic transcription / lymphocyte development. IKZF1 encodes Ikaros, a master transcription factor for lymphoid cell development controlling T cell, B cell, and NK cell differentiation.
How may the rs11978267 variant relate to Long COVID or ME/CFS?
Ikaros regulates lymphocyte development and immunological diversity; IKZF1 variants are associated with immune deficiencies and ALL; variants may affect immune competence in Long COVID.
Can a consumer DNA test detect the rs11978267 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11978267 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IKZF1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]NEJM