rs4252244

What is the rs4252244 variant?

rs4252244 is a SNP (single nucleotide polymorphism) in the IL10RA (Interleukin 10 Receptor Subunit Alpha) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL10RA encodes the alpha subunit of the IL-10 receptor, essential for transducing IL-10's anti-inflammatory signals.

Biological role and pathway

This variant sits within the IL10RA gene, which is involved in the IL-10 anti-inflammatory signaling pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL10RA

rs4252244 is one of 1 known variant in the IL10RA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4252244

Research into IL10RA variants including rs4252244 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL10RA and the rs4252244 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the IL10RA gene

The following variants in IL10RA are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions