rs2307148
Variant in the IL12RB2 gene (Interleukin 12 Receptor Subunit Beta 2)
rs2307148 is a single nucleotide polymorphism (SNP) in the IL12RB2 gene, involved in IL-12 / Th1 differentiation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2307148 variant?
rs2307148 is a SNP (single nucleotide polymorphism) in the IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL12RB2 encodes the beta-2 subunit of the IL-12 receptor, essential for IL-12-driven Th1 differentiation and IFN-gamma production.
Biological role and pathway
This variant sits within the IL12RB2 gene, which is involved in the IL-12 / Th1 differentiation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2307148 and Long COVID / ME-CFS research
IL-12 receptor signaling drives Th1 responses critical for antiviral immunity; IL12RB2 variants may affect T helper cell polarization and the quality of T cell responses in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL12RB2
rs2307148 is one of 2 known variants in the IL12RB2 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL12RB2 gene page →Conditions studied in relation to rs2307148
Research into IL12RB2 variants including rs2307148 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL12RB2 and the rs2307148 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL12RB2 gene
The following variants in IL12RB2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2307148 variant in the IL12RB2 gene?
rs2307148 is a single nucleotide polymorphism (SNP) located in the IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) gene, which is involved in IL-12 / Th1 differentiation. IL12RB2 encodes the beta-2 subunit of the IL-12 receptor, essential for IL-12-driven Th1 differentiation and IFN-gamma production.
How may the rs2307148 variant relate to Long COVID or ME/CFS?
IL-12 receptor signaling drives Th1 responses critical for antiviral immunity; IL12RB2 variants may affect T helper cell polarization and the quality of T cell responses in Long COVID.
Can a consumer DNA test detect the rs2307148 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2307148 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL12RB2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Immunology