rs20541

What is the rs20541 variant?

rs20541 is a SNP (single nucleotide polymorphism) in the IL13 (Interleukin 13) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. IL13 encodes interleukin-13, a Th2 cytokine that promotes mucus production, airway hyperresponsiveness, and IgE-mediated allergy.

Biological role and pathway

This variant sits within the IL13 gene, which is involved in the Th2 immune response pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL13

rs20541 is one of 1 known variant in the IL13 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs20541

Research into IL13 variants including rs20541 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL13 and the rs20541 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions