rs17015014
Variant in the IL15 gene (Interleukin 15)
rs17015014 is a single nucleotide polymorphism (SNP) in the IL15 gene, involved in NK and T cell homeostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs17015014 variant?
rs17015014 is a SNP (single nucleotide polymorphism) in the IL15 (Interleukin 15) gene. It belongs to the Immune Signaling category and is part of the Adaptive Immunity biological cluster. IL-15 uses the same β/γ receptor components as IL-2 but signals through trans-presentation on macrophages and DCs. It is essential for NK cell development, NK cell and CD8+ memory T cell maintenance, and antiviral immunity.
Biological role and pathway
This variant sits within the IL15 gene, which is involved in the NK and T cell homeostasis pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs17015014 and Long COVID / ME-CFS research
NK cell depletion and dysfunction in Long COVID may involve impaired IL-15 signaling. IL15 variants affecting NK cell homeostasis could reduce the surveillance capacity relevant to controlling persistent SARS-CoV-2 reservoirs and recovery from Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL15
rs17015014 is one of 3 known variants in the IL15 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL15 gene page →Conditions studied in relation to rs17015014
Research into IL15 variants including rs17015014 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL15 and the rs17015014 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL15 gene
The following variants in IL15 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs17015014 variant in the IL15 gene?
rs17015014 is a single nucleotide polymorphism (SNP) located in the IL15 (Interleukin 15) gene, which is involved in NK and T cell homeostasis. IL-15 uses the same β/γ receptor components as IL-2 but signals through trans-presentation on macrophages and DCs. It is essential for NK cell development, NK cell and CD8+ memory T cell maintenance, and antiviral immunity.
How may the rs17015014 variant relate to Long COVID or ME/CFS?
NK cell depletion and dysfunction in Long COVID may involve impaired IL-15 signaling. IL15 variants affecting NK cell homeostasis could reduce the surveillance capacity relevant to controlling persistent SARS-CoV-2 reservoirs and recovery from Long COVID.
Can a consumer DNA test detect the rs17015014 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs17015014 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL15 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32846060
- [2]Cell
- [3]Immunity