rs763780
Variant in the IL17F gene (Interleukin 17F)
rs763780 is a single nucleotide polymorphism (SNP) in the IL17F gene, involved in Th17 immune response. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs763780 variant?
rs763780 is a SNP (single nucleotide polymorphism) in the IL17F (Interleukin 17F) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL17F encodes interleukin-17F, a Th17 cytokine that acts similarly to IL-17A in recruiting neutrophils and driving mucosal inflammation.
Biological role and pathway
This variant sits within the IL17F gene, which is involved in the Th17 immune response pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs763780 and Long COVID / ME-CFS research
IL17F-driven mucosal inflammation may contribute to gastrointestinal and respiratory symptoms associated with Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL17F
rs763780 is one of 2 known variants in the IL17F gene. To understand the full biological context of this variant, explore the parent gene page.
View IL17F gene page →Conditions studied in relation to rs763780
Research into IL17F variants including rs763780 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL17F and the rs763780 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL17F gene
The following variants in IL17F are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs763780 variant in the IL17F gene?
rs763780 is a single nucleotide polymorphism (SNP) located in the IL17F (Interleukin 17F) gene, which is involved in Th17 immune response. IL17F encodes interleukin-17F, a Th17 cytokine that acts similarly to IL-17A in recruiting neutrophils and driving mucosal inflammation.
How may the rs763780 variant relate to Long COVID or ME/CFS?
IL17F-driven mucosal inflammation may contribute to gastrointestinal and respiratory symptoms associated with Long COVID.
Can a consumer DNA test detect the rs763780 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs763780 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL17F and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Journal of Clinical Investigation