rs2234650

What is the rs2234650 variant?

rs2234650 is a SNP (single nucleotide polymorphism) in the IL1R1 (Interleukin 1 Receptor Type 1) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL1R1 encodes the type I interleukin-1 receptor, transducing pro-inflammatory IL-1alpha and IL-1beta signals.

Biological role and pathway

This variant sits within the IL1R1 gene, which is involved in the IL-1 receptor signaling pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL1R1

rs2234650 is one of 1 known variant in the IL1R1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2234650

Research into IL1R1 variants including rs2234650 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL1R1 and the rs2234650 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions