rs17026974
Variant in the IL1RL1 gene (Interleukin 1 Receptor Like 1)
rs17026974 is a single nucleotide polymorphism (SNP) in the IL1RL1 gene, involved in alarmin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs17026974 variant?
rs17026974 is a SNP (single nucleotide polymorphism) in the IL1RL1 (Interleukin 1 Receptor Like 1) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL1RL1 (ST2) encodes the receptor for IL-33. Membrane-bound sST2 transduces IL-33 signals while soluble sST2 acts as a decoy receptor. IL1RL1 is a major susceptibility locus for asthma and atopic disease.
Biological role and pathway
This variant sits within the IL1RL1 gene, which is involved in the alarmin signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs17026974 and Long COVID / ME-CFS research
IL1RL1/ST2 variants are among the strongest genetic associations with asthma. Elevated soluble ST2 is a biomarker of severe COVID-19. Long COVID patients with IL1RL1 variants increasing ST2-mediated IL-33 signaling may have heightened airway and mast cell responses.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL1RL1
rs17026974 is one of 3 known variants in the IL1RL1 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL1RL1 gene page →Conditions studied in relation to rs17026974
Research into IL1RL1 variants including rs17026974 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL1RL1 and the rs17026974 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL1RL1 gene
The following variants in IL1RL1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs17026974 variant in the IL1RL1 gene?
rs17026974 is a single nucleotide polymorphism (SNP) located in the IL1RL1 (Interleukin 1 Receptor Like 1) gene, which is involved in alarmin signaling. IL1RL1 (ST2) encodes the receptor for IL-33. Membrane-bound sST2 transduces IL-33 signals while soluble sST2 acts as a decoy receptor. IL1RL1 is a major susceptibility locus for asthma and atopic disease.
How may the rs17026974 variant relate to Long COVID or ME/CFS?
IL1RL1/ST2 variants are among the strongest genetic associations with asthma. Elevated soluble ST2 is a biomarker of severe COVID-19. Long COVID patients with IL1RL1 variants increasing ST2-mediated IL-33 signaling may have heightened airway and mast cell responses.
Can a consumer DNA test detect the rs17026974 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs17026974 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL1RL1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29348502
- [2]Nature Genetics
- [3]New England Journal of Medicine