rs315952
Variant in the IL1RN gene (Interleukin 1 Receptor Antagonist)
rs315952 is a single nucleotide polymorphism (SNP) in the IL1RN gene, involved in IL-1 pathway inhibition. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs315952 variant?
rs315952 is a SNP (single nucleotide polymorphism) in the IL1RN (Interleukin 1 Receptor Antagonist) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL1RN encodes the IL-1 receptor antagonist, a natural inhibitor of IL-1 signaling that limits inflammation.
Biological role and pathway
This variant sits within the IL1RN gene, which is involved in the IL-1 pathway inhibition pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs315952 and Long COVID / ME-CFS research
IL1RN variants reducing anti-inflammatory IL-1RA production may allow unrestrained IL-1 signaling and contribute to persistent inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL1RN
rs315952 is one of 2 known variants in the IL1RN gene. To understand the full biological context of this variant, explore the parent gene page.
View IL1RN gene page →Conditions studied in relation to rs315952
Research into IL1RN variants including rs315952 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL1RN and the rs315952 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL1RN gene
The following variants in IL1RN are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs315952 variant in the IL1RN gene?
rs315952 is a single nucleotide polymorphism (SNP) located in the IL1RN (Interleukin 1 Receptor Antagonist) gene, which is involved in IL-1 pathway inhibition. IL1RN encodes the IL-1 receptor antagonist, a natural inhibitor of IL-1 signaling that limits inflammation.
How may the rs315952 variant relate to Long COVID or ME/CFS?
IL1RN variants reducing anti-inflammatory IL-1RA production may allow unrestrained IL-1 signaling and contribute to persistent inflammation in Long COVID.
Can a consumer DNA test detect the rs315952 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs315952 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL1RN and its variants. This is not an exhaustive literature review.
- [1]PMID: 29749073
- [2]Nature Genetics
- [3]Journal of Clinical Investigation