rs2069763
Variant in the IL2 gene (Interleukin 2)
rs2069763 is a single nucleotide polymorphism (SNP) in the IL2 gene, involved in T cell proliferation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2069763 variant?
rs2069763 is a SNP (single nucleotide polymorphism) in the IL2 (Interleukin 2) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL2 encodes interleukin-2, a T cell growth factor essential for T cell proliferation, differentiation, and survival.
Biological role and pathway
This variant sits within the IL2 gene, which is involved in the T cell proliferation pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2069763 and Long COVID / ME-CFS research
IL2 signaling abnormalities may contribute to T cell exhaustion and impaired immune regulation observed in Long COVID patients.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL2
rs2069763 is one of 2 known variants in the IL2 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL2 gene page →Conditions studied in relation to rs2069763
Research into IL2 variants including rs2069763 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL2 and the rs2069763 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL2 gene
The following variants in IL2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2069763 variant in the IL2 gene?
rs2069763 is a single nucleotide polymorphism (SNP) located in the IL2 (Interleukin 2) gene, which is involved in T cell proliferation. IL2 encodes interleukin-2, a T cell growth factor essential for T cell proliferation, differentiation, and survival.
How may the rs2069763 variant relate to Long COVID or ME/CFS?
IL2 signaling abnormalities may contribute to T cell exhaustion and impaired immune regulation observed in Long COVID patients.
Can a consumer DNA test detect the rs2069763 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2069763 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28416816
- [2]Nature Genetics
- [3]Journal of Clinical Investigation