rs2066808

What is the rs2066808 variant?

rs2066808 is a SNP (single nucleotide polymorphism) in the IL23A (Interleukin 23 Subunit Alpha) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL23A encodes the p19 subunit of IL-23, which drives Th17 cell maintenance and pro-inflammatory cytokine production.

Biological role and pathway

This variant sits within the IL23A gene, which is involved in the Th17 immune response pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL23A

rs2066808 is one of 1 known variant in the IL23A gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2066808

Research into IL23A variants including rs2066808 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL23A and the rs2066808 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions