rs12722489
Variant in the IL2RA gene (Interleukin 2 Receptor Alpha)
rs12722489 is a single nucleotide polymorphism (SNP) in the IL2RA gene, involved in T regulatory cell function. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs12722489 variant?
rs12722489 is a SNP (single nucleotide polymorphism) in the IL2RA (Interleukin 2 Receptor Alpha) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL2RA encodes CD25, the alpha chain of the high-affinity IL2 receptor, critical for T regulatory cell function.
Biological role and pathway
This variant sits within the IL2RA gene, which is involved in the T regulatory cell function pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs12722489 and Long COVID / ME-CFS research
IL2RA polymorphisms are associated with altered regulatory T cell activity, which may contribute to autoimmune features in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL2RA
rs12722489 is one of 2 known variants in the IL2RA gene. To understand the full biological context of this variant, explore the parent gene page.
View IL2RA gene page →Conditions studied in relation to rs12722489
Research into IL2RA variants including rs12722489 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL2RA and the rs12722489 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL2RA gene
The following variants in IL2RA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs12722489 variant in the IL2RA gene?
rs12722489 is a single nucleotide polymorphism (SNP) located in the IL2RA (Interleukin 2 Receptor Alpha) gene, which is involved in T regulatory cell function. IL2RA encodes CD25, the alpha chain of the high-affinity IL2 receptor, critical for T regulatory cell function.
How may the rs12722489 variant relate to Long COVID or ME/CFS?
IL2RA polymorphisms are associated with altered regulatory T cell activity, which may contribute to autoimmune features in Long COVID.
Can a consumer DNA test detect the rs12722489 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs12722489 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL2RA and its variants. This is not an exhaustive literature review.
- [1]PMID: 29925876
- [2]Nature Genetics
- [3]Journal of Clinical Investigation