rs3939286
Variant in the IL33 gene (Interleukin 33)
rs3939286 is a single nucleotide polymorphism (SNP) in the IL33 gene, involved in alarmin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs3939286 variant?
rs3939286 is a SNP (single nucleotide polymorphism) in the IL33 (Interleukin 33) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL-33 is a nuclear alarmin cytokine released by damaged epithelial and endothelial cells that activates mast cells, ILC2s, and eosinophils through ST2 (IL1RL1). It is a key driver of type 2 immune responses and tissue repair signaling.
Biological role and pathway
This variant sits within the IL33 gene, which is involved in the alarmin signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs3939286 and Long COVID / ME-CFS research
IL-33 release from damaged lung epithelium during COVID-19 may drive ILC2 activation and airway hyperreactivity contributing to Long COVID respiratory symptoms. IL33 variants associated with asthma and atopic disease may increase susceptibility to respiratory Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL33
rs3939286 is one of 3 known variants in the IL33 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL33 gene page →Conditions studied in relation to rs3939286
Research into IL33 variants including rs3939286 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL33 and the rs3939286 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL33 gene
The following variants in IL33 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs3939286 variant in the IL33 gene?
rs3939286 is a single nucleotide polymorphism (SNP) located in the IL33 (Interleukin 33) gene, which is involved in alarmin signaling. IL-33 is a nuclear alarmin cytokine released by damaged epithelial and endothelial cells that activates mast cells, ILC2s, and eosinophils through ST2 (IL1RL1). It is a key driver of type 2 immune responses and tissue repair signaling.
How may the rs3939286 variant relate to Long COVID or ME/CFS?
IL-33 release from damaged lung epithelium during COVID-19 may drive ILC2 activation and airway hyperreactivity contributing to Long COVID respiratory symptoms. IL33 variants associated with asthma and atopic disease may increase susceptibility to respiratory Long COVID.
Can a consumer DNA test detect the rs3939286 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs3939286 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL33 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29540327
- [2]Nature Immunology
- [3]New England Journal of Medicine