rs3811047

What is the rs3811047 variant?

rs3811047 is a SNP (single nucleotide polymorphism) in the IL37 (Interleukin 37) gene. It belongs to the Immune Signaling category and is part of the Cytokines & Immune Signaling biological cluster. IL37 encodes a broadly anti-inflammatory cytokine that suppresses innate and adaptive immune responses via interleukin-18 receptor complex.

Biological role and pathway

This variant sits within the IL37 gene, which is involved in the anti-inflammatory cytokine signaling pathway. Genes within the Cytokines & Immune Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL37

rs3811047 is one of 1 known variant in the IL37 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3811047

Research into IL37 variants including rs3811047 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL37 and the rs3811047 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions