rs2243250

What is the rs2243250 variant?

rs2243250 is a SNP (single nucleotide polymorphism) in the IL4 (Interleukin 4) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. IL4 encodes interleukin-4, a Th2 cytokine that drives IgE class switching, mast cell differentiation, and allergic responses.

Biological role and pathway

This variant sits within the IL4 gene, which is involved in the Th2 immune response pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: IL4

rs2243250 is one of 1 known variant in the IL4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2243250

Research into IL4 variants including rs2243250 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL4 and the rs2243250 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions