rs1801275
Variant in the IL4RA gene (Interleukin 4 Receptor Subunit Alpha)
rs1801275 is a single nucleotide polymorphism (SNP) in the IL4RA gene, involved in IL-4 / IL-13 receptor / Th2 signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1801275 variant?
rs1801275 is a SNP (single nucleotide polymorphism) in the IL4RA (Interleukin 4 Receptor Subunit Alpha) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL4RA encodes the IL-4 receptor alpha subunit, which forms part of both the IL-4 and IL-13 receptors, driving Th2 responses.
Biological role and pathway
This variant sits within the IL4RA gene, which is involved in the IL-4 / IL-13 receptor / Th2 signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1801275 and Long COVID / ME-CFS research
IL4RA variants (Ile50Val, Gln576Arg) are strongly associated with atopic disease; Th2-biased immune responses and mast cell activation may contribute to histamine intolerance and MCAS in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL4RA
rs1801275 is one of 2 known variants in the IL4RA gene. To understand the full biological context of this variant, explore the parent gene page.
View IL4RA gene page →Conditions studied in relation to rs1801275
Research into IL4RA variants including rs1801275 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL4RA and the rs1801275 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL4RA gene
The following variants in IL4RA are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1801275 variant in the IL4RA gene?
rs1801275 is a single nucleotide polymorphism (SNP) located in the IL4RA (Interleukin 4 Receptor Subunit Alpha) gene, which is involved in IL-4 / IL-13 receptor / Th2 signaling. IL4RA encodes the IL-4 receptor alpha subunit, which forms part of both the IL-4 and IL-13 receptors, driving Th2 responses.
How may the rs1801275 variant relate to Long COVID or ME/CFS?
IL4RA variants (Ile50Val, Gln576Arg) are strongly associated with atopic disease; Th2-biased immune responses and mast cell activation may contribute to histamine intolerance and MCAS in Long COVID.
Can a consumer DNA test detect the rs1801275 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1801275 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL4RA and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]NEJM