rs2069812
Variant in the IL5 gene (Interleukin 5)
rs2069812 is a single nucleotide polymorphism (SNP) in the IL5 gene, involved in eosinophil differentiation / Th2 effector. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2069812 variant?
rs2069812 is a SNP (single nucleotide polymorphism) in the IL5 (Interleukin 5) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. IL5 encodes interleukin-5, the primary cytokine for eosinophil differentiation, survival, and activation.
Biological role and pathway
This variant sits within the IL5 gene, which is involved in the eosinophil differentiation / Th2 effector pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2069812 and Long COVID / ME-CFS research
Eosinophil dynamics are altered in COVID-19; IL5 variants affecting eosinophil differentiation may influence eosinophilic inflammation and MCAS-like features in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL5
rs2069812 is one of 2 known variants in the IL5 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL5 gene page →Conditions studied in relation to rs2069812
Research into IL5 variants including rs2069812 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL5 and the rs2069812 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL5 gene
The following variants in IL5 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2069812 variant in the IL5 gene?
rs2069812 is a single nucleotide polymorphism (SNP) located in the IL5 (Interleukin 5) gene, which is involved in eosinophil differentiation / Th2 effector. IL5 encodes interleukin-5, the primary cytokine for eosinophil differentiation, survival, and activation.
How may the rs2069812 variant relate to Long COVID or ME/CFS?
Eosinophil dynamics are altered in COVID-19; IL5 variants affecting eosinophil differentiation may influence eosinophilic inflammation and MCAS-like features in Long COVID.
Can a consumer DNA test detect the rs2069812 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2069812 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL5 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]Journal of Allergy and Clinical Immunology