rs8179182
Variant in the IL6ST gene (Interleukin 6 Signal Transducer (gp130))
rs8179182 is a single nucleotide polymorphism (SNP) in the IL6ST gene, involved in IL-6 / gp130 / JAK-STAT3 signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs8179182 variant?
rs8179182 is a SNP (single nucleotide polymorphism) in the IL6ST (Interleukin 6 Signal Transducer (gp130)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL6ST encodes gp130, the signal-transducing receptor subunit shared by IL-6, IL-11, IL-27, and other cytokines.
Biological role and pathway
This variant sits within the IL6ST gene, which is involved in the IL-6 / gp130 / JAK-STAT3 signaling pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs8179182 and Long COVID / ME-CFS research
gp130 is the shared signal transducer for multiple inflammatory cytokines elevated in Long COVID; variants may modulate the magnitude of JAK-STAT3 inflammatory signaling.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL6ST
rs8179182 is one of 2 known variants in the IL6ST gene. To understand the full biological context of this variant, explore the parent gene page.
View IL6ST gene page →Conditions studied in relation to rs8179182
Research into IL6ST variants including rs8179182 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL6ST and the rs8179182 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL6ST gene
The following variants in IL6ST are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs8179182 variant in the IL6ST gene?
rs8179182 is a single nucleotide polymorphism (SNP) located in the IL6ST (Interleukin 6 Signal Transducer (gp130)) gene, which is involved in IL-6 / gp130 / JAK-STAT3 signaling. IL6ST encodes gp130, the signal-transducing receptor subunit shared by IL-6, IL-11, IL-27, and other cytokines.
How may the rs8179182 variant relate to Long COVID or ME/CFS?
gp130 is the shared signal transducer for multiple inflammatory cytokines elevated in Long COVID; variants may modulate the magnitude of JAK-STAT3 inflammatory signaling.
Can a consumer DNA test detect the rs8179182 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs8179182 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL6ST and its variants. This is not an exhaustive literature review.
- [1]PMID: 29749073
- [2]Nature Genetics
- [3]Journal of Clinical Investigation