rs1494555
Variant in the IL7R gene (Interleukin 7 Receptor (CD127))
rs1494555 is a single nucleotide polymorphism (SNP) in the IL7R gene, involved in T cell homeostasis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1494555 variant?
rs1494555 is a SNP (single nucleotide polymorphism) in the IL7R (Interleukin 7 Receptor (CD127)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. IL7R encodes CD127, the alpha subunit of the IL-7 receptor, essential for T cell development and homeostatic survival.
Biological role and pathway
This variant sits within the IL7R gene, which is involved in the T cell homeostasis pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1494555 and Long COVID / ME-CFS research
IL7R variants (particularly rs6897932) affect IL-7 receptor function; reduced CD127 expression on T cells in COVID-19 may impair homeostatic T cell maintenance in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL7R
rs1494555 is one of 2 known variants in the IL7R gene. To understand the full biological context of this variant, explore the parent gene page.
View IL7R gene page →Conditions studied in relation to rs1494555
Research into IL7R variants including rs1494555 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL7R and the rs1494555 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL7R gene
The following variants in IL7R are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1494555 variant in the IL7R gene?
rs1494555 is a single nucleotide polymorphism (SNP) located in the IL7R (Interleukin 7 Receptor (CD127)) gene, which is involved in T cell homeostasis. IL7R encodes CD127, the alpha subunit of the IL-7 receptor, essential for T cell development and homeostatic survival.
How may the rs1494555 variant relate to Long COVID or ME/CFS?
IL7R variants (particularly rs6897932) affect IL-7 receptor function; reduced CD127 expression on T cells in COVID-19 may impair homeostatic T cell maintenance in Long COVID.
Can a consumer DNA test detect the rs1494555 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1494555 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL7R and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]NEJM