rs2227306
Variant in the IL8 gene (Interleukin 8 (CXCL8))
rs2227306 is a single nucleotide polymorphism (SNP) in the IL8 gene, involved in neutrophil recruitment. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2227306 variant?
rs2227306 is a SNP (single nucleotide polymorphism) in the IL8 (Interleukin 8 (CXCL8)) gene. It belongs to the Chemokine category and is part of the Chemokines biological cluster. IL8 (now officially CXCL8) encodes a potent neutrophil chemoattractant that is among the earliest cytokines released during infection.
Biological role and pathway
This variant sits within the IL8 gene, which is involved in the neutrophil recruitment pathway. Genes within the Chemokines cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2227306 and Long COVID / ME-CFS research
Elevated CXCL8 drives neutrophil-mediated inflammation and tissue damage; its dysregulation contributes to pulmonary and systemic inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL8
rs2227306 is one of 2 known variants in the IL8 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL8 gene page →Conditions studied in relation to rs2227306
Research into IL8 variants including rs2227306 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL8 and the rs2227306 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL8 gene
The following variants in IL8 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2227306 variant in the IL8 gene?
rs2227306 is a single nucleotide polymorphism (SNP) located in the IL8 (Interleukin 8 (CXCL8)) gene, which is involved in neutrophil recruitment. IL8 (now officially CXCL8) encodes a potent neutrophil chemoattractant that is among the earliest cytokines released during infection.
How may the rs2227306 variant relate to Long COVID or ME/CFS?
Elevated CXCL8 drives neutrophil-mediated inflammation and tissue damage; its dysregulation contributes to pulmonary and systemic inflammation in Long COVID.
Can a consumer DNA test detect the rs2227306 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2227306 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for IL8 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Journal of Clinical Investigation