rs31563
Variant in the IL9 gene (Interleukin 9)
rs31563 is a single nucleotide polymorphism (SNP) in the IL9 gene, involved in Th9 / mast cell and eosinophil activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs31563 variant?
rs31563 is a SNP (single nucleotide polymorphism) in the IL9 (Interleukin 9) gene. It belongs to the Immune Signaling category and is part of the Histamine & MCAS biological cluster. IL9 encodes interleukin-9, produced by Th9 cells, which activates mast cells and promotes eosinophil survival.
Biological role and pathway
This variant sits within the IL9 gene, which is involved in the Th9 / mast cell and eosinophil activation pathway. Genes within the Histamine & MCAS cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs31563 and Long COVID / ME-CFS research
IL-9-driven mast cell activation may contribute to MCAS and histamine intolerance in Long COVID; variants may affect mast cell sensitivity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IL9
rs31563 is one of 1 known variant in the IL9 gene. To understand the full biological context of this variant, explore the parent gene page.
View IL9 gene page →Conditions studied in relation to rs31563
Research into IL9 variants including rs31563 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IL9 and the rs31563 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IL9 gene
The following variants in IL9 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs31563 variant in the IL9 gene?
rs31563 is a single nucleotide polymorphism (SNP) located in the IL9 (Interleukin 9) gene, which is involved in Th9 / mast cell and eosinophil activation. IL9 encodes interleukin-9, produced by Th9 cells, which activates mast cells and promotes eosinophil survival.
How may the rs31563 variant relate to Long COVID or ME/CFS?
IL-9-driven mast cell activation may contribute to MCAS and histamine intolerance in Long COVID; variants may affect mast cell sensitivity.
Can a consumer DNA test detect the rs31563 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID MCAS: Mast Cells, Histamine and Your Genes
Learn how Long COVID MCAS may develop, how it overlaps with POTS and histamine intolerance, and which genes research links to mast cell activity.
Find out if you carry the rs31563 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IL9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33398161
- [2]Nature Genetics
- [3]Journal of Allergy and Clinical Immunology