rs689
Variant in the INS gene (Insulin)
rs689 is a single nucleotide polymorphism (SNP) in the INS gene, involved in glucose metabolism / insulin secretion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs689 variant?
rs689 is a SNP (single nucleotide polymorphism) in the INS (Insulin) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. INS encodes insulin, the primary anabolic hormone secreted by pancreatic beta cells that regulates glucose uptake.
Biological role and pathway
This variant sits within the INS gene, which is involved in the glucose metabolism / insulin secretion pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs689 and Long COVID / ME-CFS research
SARS-CoV-2 infects pancreatic beta cells and can impair insulin secretion; INS variants may affect baseline insulin production capacity and susceptibility to post-COVID diabetes.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: INS
rs689 is one of 2 known variants in the INS gene. To understand the full biological context of this variant, explore the parent gene page.
View INS gene page →Conditions studied in relation to rs689
Research into INS variants including rs689 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include INS and the rs689 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the INS gene
The following variants in INS are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs689 variant in the INS gene?
rs689 is a single nucleotide polymorphism (SNP) located in the INS (Insulin) gene, which is involved in glucose metabolism / insulin secretion. INS encodes insulin, the primary anabolic hormone secreted by pancreatic beta cells that regulates glucose uptake.
How may the rs689 variant relate to Long COVID or ME/CFS?
SARS-CoV-2 infects pancreatic beta cells and can impair insulin secretion; INS variants may affect baseline insulin production capacity and susceptibility to post-COVID diabetes.
Can a consumer DNA test detect the rs689 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs689 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for INS and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM