rs1799817
Variant in the INSR gene (Insulin Receptor)
rs1799817 is a single nucleotide polymorphism (SNP) in the INSR gene, involved in insulin signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1799817 variant?
rs1799817 is a SNP (single nucleotide polymorphism) in the INSR (Insulin Receptor) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. INSR encodes the insulin receptor, through which insulin signals to regulate glucose uptake, cell growth, and metabolism.
Biological role and pathway
This variant sits within the INSR gene, which is involved in the insulin signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1799817 and Long COVID / ME-CFS research
Insulin resistance markers are elevated in Long COVID; INSR variants may influence metabolic and immune responses in post-COVID syndrome.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: INSR
rs1799817 is one of 2 known variants in the INSR gene. To understand the full biological context of this variant, explore the parent gene page.
View INSR gene page →Conditions studied in relation to rs1799817
Research into INSR variants including rs1799817 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include INSR and the rs1799817 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the INSR gene
The following variants in INSR are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1799817 variant in the INSR gene?
rs1799817 is a single nucleotide polymorphism (SNP) located in the INSR (Insulin Receptor) gene, which is involved in insulin signaling. INSR encodes the insulin receptor, through which insulin signals to regulate glucose uptake, cell growth, and metabolism.
How may the rs1799817 variant relate to Long COVID or ME/CFS?
Insulin resistance markers are elevated in Long COVID; INSR variants may influence metabolic and immune responses in post-COVID syndrome.
Can a consumer DNA test detect the rs1799817 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1799817 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for INSR and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]Journal of Clinical Investigation