rs4251545
Variant in the IRAK4 gene (Interleukin 1 Receptor Associated Kinase 4)
rs4251545 is a single nucleotide polymorphism (SNP) in the IRAK4 gene, involved in TLR signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4251545 variant?
rs4251545 is a SNP (single nucleotide polymorphism) in the IRAK4 (Interleukin 1 Receptor Associated Kinase 4) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Interferons biological cluster. IRAK4 is the first kinase recruited to MyD88 signalosome complexes, essential for signal transduction from TLRs and IL-1 family receptors. Its catalytic activity is required for full inflammatory signaling.
Biological role and pathway
This variant sits within the IRAK4 gene, which is involved in the TLR signaling pathway. Genes within the Innate Immunity & Interferons cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4251545 and Long COVID / ME-CFS research
Inherited IRAK4 deficiency causes recurrent bacterial infections in childhood with reduced TLR/IL-1R signaling. IRAK4 variants may influence the quality and duration of innate immune responses to SARS-CoV-2 relevant to Long COVID predisposition.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IRAK4
rs4251545 is one of 3 known variants in the IRAK4 gene. To understand the full biological context of this variant, explore the parent gene page.
View IRAK4 gene page →Conditions studied in relation to rs4251545
Research into IRAK4 variants including rs4251545 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IRAK4 and the rs4251545 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IRAK4 gene
The following variants in IRAK4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4251545 variant in the IRAK4 gene?
rs4251545 is a single nucleotide polymorphism (SNP) located in the IRAK4 (Interleukin 1 Receptor Associated Kinase 4) gene, which is involved in TLR signaling. IRAK4 is the first kinase recruited to MyD88 signalosome complexes, essential for signal transduction from TLRs and IL-1 family receptors. Its catalytic activity is required for full inflammatory signaling.
How may the rs4251545 variant relate to Long COVID or ME/CFS?
Inherited IRAK4 deficiency causes recurrent bacterial infections in childhood with reduced TLR/IL-1R signaling. IRAK4 variants may influence the quality and duration of innate immune responses to SARS-CoV-2 relevant to Long COVID predisposition.
Can a consumer DNA test detect the rs4251545 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4251545 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IRAK4 and its variants. This is not an exhaustive literature review.
- [1]PMID: 23974675
- [2]Journal of Clinical Investigation
- [3]Immunity