rs2305740
Variant in the IRF9 gene (Interferon Regulatory Factor 9)
rs2305740 is a single nucleotide polymorphism (SNP) in the IRF9 gene, involved in type I interferon / ISGF3 complex. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2305740 variant?
rs2305740 is a SNP (single nucleotide polymorphism) in the IRF9 (Interferon Regulatory Factor 9) gene. It belongs to the Antiviral category and is part of the Viral Defense & Interferon Response biological cluster. IRF9 encodes the DNA-binding component of ISGF3 (together with STAT1 and STAT2), which activates interferon-stimulated gene expression.
Biological role and pathway
This variant sits within the IRF9 gene, which is involved in the type I interferon / ISGF3 complex pathway. Genes within the Viral Defense & Interferon Response cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2305740 and Long COVID / ME-CFS research
IRF9/ISGF3 is essential for type I interferon gene induction; variants may affect the robustness of antiviral ISG expression and the resolution of viral infection in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: IRF9
rs2305740 is one of 1 known variant in the IRF9 gene. To understand the full biological context of this variant, explore the parent gene page.
View IRF9 gene page →Conditions studied in relation to rs2305740
Research into IRF9 variants including rs2305740 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include IRF9 and the rs2305740 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the IRF9 gene
The following variants in IRF9 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2305740 variant in the IRF9 gene?
rs2305740 is a single nucleotide polymorphism (SNP) located in the IRF9 (Interferon Regulatory Factor 9) gene, which is involved in type I interferon / ISGF3 complex. IRF9 encodes the DNA-binding component of ISGF3 (together with STAT1 and STAT2), which activates interferon-stimulated gene expression.
How may the rs2305740 variant relate to Long COVID or ME/CFS?
IRF9/ISGF3 is essential for type I interferon gene induction; variants may affect the robustness of antiviral ISG expression and the resolution of viral infection in Long COVID.
Can a consumer DNA test detect the rs2305740 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2305740 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for IRF9 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32217835
- [2]Nature Immunology
- [3]Journal of Immunology