rs505922
Variant in the ITGA2 gene (Integrin Subunit Alpha 2)
rs505922 is a single nucleotide polymorphism (SNP) in the ITGA2 gene, involved in platelet collagen adhesion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs505922 variant?
rs505922 is a SNP (single nucleotide polymorphism) in the ITGA2 (Integrin Subunit Alpha 2) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. ITGA2 (α2 integrin, CD49b) forms α2β1 integrin (GPIa-IIa, VLA-2) on platelets and T cells, providing a secondary collagen receptor that supports platelet adhesion and immune cell matrix interactions.
Biological role and pathway
This variant sits within the ITGA2 gene, which is involved in the platelet collagen adhesion pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs505922 and Long COVID / ME-CFS research
ITGA2 C807T (rs1126643) affects platelet collagen receptor density and has been associated with cardiovascular thrombotic risk. Variations in platelet collagen adhesion capacity through ITGA2 may modulate platelet-driven vascular occlusion in Long COVID coagulopathy.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ITGA2
rs505922 is one of 3 known variants in the ITGA2 gene. To understand the full biological context of this variant, explore the parent gene page.
View ITGA2 gene page →Conditions studied in relation to rs505922
Research into ITGA2 variants including rs505922 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ITGA2 and the rs505922 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ITGA2 gene
The following variants in ITGA2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs505922 variant in the ITGA2 gene?
rs505922 is a single nucleotide polymorphism (SNP) located in the ITGA2 (Integrin Subunit Alpha 2) gene, which is involved in platelet collagen adhesion. ITGA2 (α2 integrin, CD49b) forms α2β1 integrin (GPIa-IIa, VLA-2) on platelets and T cells, providing a secondary collagen receptor that supports platelet adhesion and immune cell matrix interactions.
How may the rs505922 variant relate to Long COVID or ME/CFS?
ITGA2 C807T (rs1126643) affects platelet collagen receptor density and has been associated with cardiovascular thrombotic risk. Variations in platelet collagen adhesion capacity through ITGA2 may modulate platelet-driven vascular occlusion in Long COVID coagulopathy.
Can a consumer DNA test detect the rs505922 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs505922 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for ITGA2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28167844
- [2]Thrombosis and Haemostasis
- [3]Journal of Thrombosis and Haemostasis