rs1143674
Variant in the ITGA4 gene (Integrin Subunit Alpha 4)
rs1143674 is a single nucleotide polymorphism (SNP) in the ITGA4 gene, involved in leukocyte trafficking. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1143674 variant?
rs1143674 is a SNP (single nucleotide polymorphism) in the ITGA4 (Integrin Subunit Alpha 4) gene. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. ITGA4 (CD49d) forms α4β1 (VLA-4) and α4β7 integrins that mediate lymphocyte adhesion to endothelial VCAM-1 and MadCAM-1, directing T cell trafficking to inflammatory sites and the gut respectively. Natalizumab targets α4 for MS treatment.
Biological role and pathway
This variant sits within the ITGA4 gene, which is involved in the leukocyte trafficking pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1143674 and Long COVID / ME-CFS research
Leukocyte transmigration through activated endothelium is elevated in COVID-19-associated vascular disease. ITGA4 variants affecting lymphocyte adhesion and migration into inflamed tissues may influence the degree of immune cell infiltration in Long COVID organ pathology.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: ITGA4
rs1143674 is one of 3 known variants in the ITGA4 gene. To understand the full biological context of this variant, explore the parent gene page.
View ITGA4 gene page →Conditions studied in relation to rs1143674
Research into ITGA4 variants including rs1143674 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include ITGA4 and the rs1143674 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the ITGA4 gene
The following variants in ITGA4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1143674 variant in the ITGA4 gene?
rs1143674 is a single nucleotide polymorphism (SNP) located in the ITGA4 (Integrin Subunit Alpha 4) gene, which is involved in leukocyte trafficking. ITGA4 (CD49d) forms α4β1 (VLA-4) and α4β7 integrins that mediate lymphocyte adhesion to endothelial VCAM-1 and MadCAM-1, directing T cell trafficking to inflammatory sites and the gut respectively. Natalizumab targets α4 for MS treatment.
How may the rs1143674 variant relate to Long COVID or ME/CFS?
Leukocyte transmigration through activated endothelium is elevated in COVID-19-associated vascular disease. ITGA4 variants affecting lymphocyte adhesion and migration into inflamed tissues may influence the degree of immune cell infiltration in Long COVID organ pathology.
Can a consumer DNA test detect the rs1143674 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1143674 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for ITGA4 and its variants. This is not an exhaustive literature review.
- [1]PMID: 29217062
- [2]Nature Reviews Immunology
- [3]Cell